Thyroxine replacement promptly corrects vaginal bleeding in precocious menarche due to Van Wyk Grumbach syndrome
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چکیده
منابع مشابه
A Case of Van Wyk-Grumbach Syndrome
In boys precocious puberty is defined as the development of secondary sexual characters before 9 year of age. In girls, the development of breasts (thelarche) before 7.5 year, the development of pubic hairs (pubarche) before 8.5 year or menarche before the age of 9.5 year is considered precocious [1]. Hypothyroidism is usually associated with delayed puberty and rarely with precocious puberty [...
متن کاملAn unusual presentation of girl with down syndrome: Van-Wyk Grumbach syndrome
Van Wyk-Grumbach syndrome is a rare disease characterized by precocious puberty associated with prolonged hypothyroidism and multicystic enlarged ovaries. A9 year-old girl with Down syndrome visited our hospital for early menarche. At birth, she showed subclinical hypothyroidism (11.8 mg/dL of thyroxine (T4) and 6.05 mIU/mL of thyroid stimulating hormone (TSH)), but she had not been followed up...
متن کاملAn unusual presentation of acquired hypothyroidism: the Van Wyk-Grumbach syndrome.
The association in young females of long-standing primary hypothyroidism, isosexual precocious pseudopuberty and multicystic enlarged ovaries was first described in 1960 by Van Wyk and Grumbach. Since then, sporadic case reports have contributed to clarifying the key features of this syndrome. The unique elements that lead to this diagnosis are FSH-dominated sexual precocity combined with a del...
متن کاملPrecocious Puberty: An Unusual Presentation of Hypothyroidism
Hypothyroidism is usually associated with delayed pubertal development but in rare occasions precocious puberty may ensue which is seen in cases of prolonged and untreated hypothyroidism. This is also called the Van Wyk Grumbach syndrome. Here we present 4 cases of precocious puberty due to hypothyroidism.
متن کاملVan Wyk Award acceptance speech.
The Van Wyk Prize is the Lawson Wilkins Pediatric Endocrine Society (LPWES)’s most prestigious award in recognition of outstanding career achievement by a member in the field of pediatric endocrinology. This award, established in honor of Judson J. Van Wyk, M.D., stands in tribute to an outstanding leader who has displayed a career of scientific excellence, leadership and dedication to the heal...
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ژورنال
عنوان ژورنال: International Journal of Contemporary Pediatrics
سال: 2015
ISSN: 2349-3283
DOI: 10.5455/2349-3291.ijcp20150518